Fig. 5.

cPLA2 inhibitor decreases S100A7-mediated recruitment of myeloid-derived suppressor cells (MDSCs) in MMTV-rtTA;TetO-mS100a7a15 bi-transgenic mice model (A). Flow cytometric and (B). t-SNE plot analysis of CD11b⁺Gr-1⁺ MDSCs (out of CD45⁺) in spleens harvested from Tet-off and Tet-on mice treated with VC or AF3 (C). Bar diagram represents the means ±SEMs of three replicates (D). Flow cytometric and (E). t-SNE plot analysis of MDSCs in tumors harvested from Tet-off and Tet-on mice treated with VC or AF3 (F). Bar diagram represents the means ±SEMs of three replicates. ns: non-significant, *P < 0.05, ** P < 0.01, *** P < 0.001. One way ANOVA was used for multiple group comparisons