Fig. 3.

Gas6 expression reduces plaque number in male APP/PS1 mice. A Representative images from male and female APP mice injected with AAV-Gas6 or AAV-control at 9 months of age and injected with MX-04 24 h before sacrifice at 10 mo. Scale bar is 100 μm. B, C Quantitative measurements of % area of MX-04 and plaque numbers. N = 7–10 mice per group. Error bars represent mean ± SEM. Unpaired two-tailed t-test **p = 0.0014. D Particle analysis on MX-04 positive plaques. N = 7–10 mice per group. Error bars represent mean ± SEM. Two-way ANOVA **p < 0.01