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. 2022 Feb 7;19:38. doi: 10.1186/s12974-022-02397-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — RNAseq of AAV-Gas6 treated APP/PS1 mice microglia reveals an enrichment of transcriptional signatures related to interferon response. A PCA plot of microglial samples. B Heatmap showing significantly DEGs between microglia isolated from AAV-Gas6 treated APP/PS1 mice and AAV-control hippocampi. Colors are shown in logarithmic scale. C Volcano plot with significantly downregulated genes (shown in red) and significantly upregulated genes (shown in green). Genes with a p-value < 0.001 are labeled. Vertical line is the p = 0.05 cutoff and horizontal lines show log2FoldChange = − 1 or 1. D Overrepresentation test of significantly upregulated genes through clusterProfiler package shows enrichment for interferon-gamma and beta response related pathways. E, F CXCL13 and CCL2 ELISA on hippocampal protein lysates from Gas6 and control-treated mice. Two-way ANOVA followed by Tukey post-hoc **p = 0.0018, ^#p = 0.0878