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. 2022 Feb 7;19:41. doi: 10.1186/s12974-022-02400-6

Fig. 16.

Fig. 16

Knockdown Gpx4 in the Hip antagonized the antidepressant and anxiolytic effects of EDA. A Schematic timeline of the experimental procedure. B Fluorescence image of a fixed brain section that expressed AAV2/8-CMV–EGFP–miRNAi(Gpx4) in the Hip. Scale bar, 500 μm. C Social interaction test. D Sucrose preference test. E Open field test. F Elevated plus maze test. G Tail suspension test. H Forced swimming test. I Novel object recognition test. All the data are expressed as mean ± SEM (n = 10 per group). ***p < 0.001 versus the CON group. #p < 0.05, ##p < 0.01, ###p < 0.001 versus the CSDS group. &p < 0.05, &&p < 0.01 versus the CSDS + EDA group