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. 2022 Feb 8;22:65. doi: 10.1186/s12935-022-02479-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Decreased expression of PTPN14 in HCC. A PTPN14 mRNA levels in 20 paired HCC and corresponding peritumoral liver tissues were evaluated by qRT-PCR. B PTPN14 protein levels in tumor tissues (T) and the paired adjacent non-tumor tissues (P) from four HCC patients were examined by western blotting. C Representative cases of PTPN14 IHC staining in HCC and corresponding peritumoral liver tissues by tissue microarray. Scale bar = 50 μm. D Relative H-score of PTPN14 in paired HCC and corresponding peritumoral liver tissue samples (n = 77). Statistical significance was determined by Student’s t tests. **p < 0.01, ***p < 0.001