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. 2022 Jan 25;25(3):101. doi: 10.3892/mmr.2022.12617

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Knockdown of ATG4A enhances the sensitivity of breast cancer cells to tamoxifen. (A and B) The expression of ATG4A in MCF7/R cells was determined using western blot analysis. (C) Cell viability was detected with Cell Counting Kit-8 assay. (D) Apoptosis was detected using flow cytometric analysis. (E) The expression of apoptosis-related proteins (Bcl-2 and Bax) was analyzed using western blot analysis. **P<0.01 vs. control group; ^##P<0.01 vs. 4-OHT + sh-NC group. ATG4A, autophagy-related 4A; 4-OHT, 4-hydroxytamoxifen; sh-, short hairpin; NC, negative control.