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. 2022 Feb 7;10(2):e003465. doi: 10.1136/jitc-2021-003465

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Cytotoxic immune response regulation is the main function of ITGB6 within the tumor. (A) Heatmap of differentially expressed genes (DEGs) (p<0.001) in MC38-ITGB6 and MC38-Ctrl tumors, generated by unsupervised hierarchical clustering (n=5 mice). (B) Volcano plot displaying DEGs from MC38-ITGB6 versus MC38-Ctrl tumors. Y-axis corresponds to p value of –log 10. X-axis displays log 2-fold change value. Indicated limits represent DEGs with p<0.05 and log 2 fold change above +2 or below −2. (C) Gene ontology enrichment analysis of DEGs. Bars in red or blue indicate the number of genes involved in upregulation or downregulation of the respective biological process in ITGB6-expressing tumors.