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. 2022 Feb 7;10(2):e003527. doi: 10.1136/jitc-2021-003527

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Association between sPD-L1 and response. Serum level of sPD-L1 in patients from CheckMate 009 (upper panels) and CheckMate038 (middle panels). BOR is indicated by gold squares (PD), blue circles (SD) or aqua triangles (CR or PR). All p values are derived from Wilcoxon rank sum test. (A) Samples provided at baseline in CheckMate 009. Data are grouped by BOR (PD, SD or CRPR, n=27, 42, 14, respectively). (B) Samples provided at day 29 in CheckMate 009. Data are grouped by BOR (PD, SD or CRPR, n=27, 41, 14 respectively). (C) Samples provided at day 63 in CheckMate 009. Data are grouped by BOR (PD, SD or CRPR, n=16, 39, 13, respectively). (D) Samples provided at baseline in CheckMate 038-P1. Data are grouped by BOR (PD, SD or CRPR, n=34, 24, 20, respectively). (E) Samples provided at day 29 in CheckMate 038-P1. Data are grouped by BOR (PD, SD or CRPR, n=28, 24, 17, respectively). (F) Samples provided at day 43 in CheckMate 038-P1. Data are grouped by BOR (PD, SD or CRPR, n=23, 22, 19, respectively). (G) Cox proportional hazard analysis of survival in CheckMate 009, comparing patients from the highest tertile of sPD-L1 values to patients from the lowest tertile of values, for each timepoint indicated. Panel displays p value and zero-centered HR. HR and 95% CIs are indicated to left. (H) Cox proportional hazard analysis of survival in CheckMate 038-P1, comparing patients from the highest tertile of sPD-L1 values to patients from the lowest tertile of values, for each timepoint indicated. Panel displays p value and zero-centered HR. HR and 95% CIs are indicated to left. BOR, best overall response; CR, complete response; OS, overall survival; PFS, progression-free survival; PD, progressive disease; PR, partial response; SD, stable disease.