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. 2022 Feb 7;10(2):e003527. doi: 10.1136/jitc-2021-003527

Figure 5.

Figure 5

Association between change in sPD-L1 on therapy and outcome. Data shown are for patients from CheckMate 009 (upper panels) and CheckMate038 (middle panels). Partition at the median change uses sPD-L1 values given in table 1. (A) Level of sPD-L1 at baseline and day 29 in CheckMate 009 patients with both values (n=79), grouped by BOR. Lines connect values for each patient. P values from paired t-test (two sided). (B) Level of sPD-L1 at baseline and day 63 in CheckMate 009 patients with both values (n=63), grouped by BOR. Lines connect values for each patient. P values from paired t-test (two sided). (C) Rate of refractory patients (best response of PD in CheckMate 009) in groups based on partition at the median change of sPD-L1. Data presented using partition by median change in sPD-L1 at Day 29 (n=79) and median change at day 63 (n=63). P values from Fisher’s exact test. (D) Level of sPD-L1 at baseline and day 29 in CheckMate 038-P1 patients with both values (n=79), grouped by BOR. Lines connect values for each patient. P values from paired t-test (two sided). (E) Level of sPD-L1 at baseline and day 63 in CheckMate 038-P1 patients with both values (n=63C), grouped by BOR. Lines connect values for each patient. P values from paired t-test (two-sided). (F) ROC curve summarizing predictive accuracy for the change in sPD-L1 at day 43 in CheckMate 038 patients with cutaneous melanoma (n=37, AUC=67%, 95% CI 48% to 86%). The observation nearest the median value of change in sPD-L1 at Day 43 in all patients (171 pg/mL) is indicated. (G) Cox proportional hazard analysis of survival in CheckMate 009, comparing patients based on partition at the median change of sPD-L1, for each timepoint indicated. Panel displays p value and zero-centered HR. HR and 95% CIs are indicated to left. (H) Cox proportional hazard analysis of survival in CheckMate 038-P1, comparing patients based on partition at the median change of sPD-L1, for each timepoint indicated. Panel displays p value and zero-centered HR. HR and 95% CIs are indicated to left. AUC, area under curve; BOR, best overall response; CR, complete response; OS, overall survival; PFS, progression-free survival; PD, progressive disease; PR, partial response; SD, stable disease.