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. 2022 Jan 25;9:784024. doi: 10.3389/fped.2021.784024

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Copyright © 2022 Buechner, Caruana, Künkele, Rives, Vettenranta, Bader, Peters, Baruchel and Calkoen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed approach to HSCT consolidation after CAR-T for paediatric patients and AYA with BCP-ALL based on treatment- and disease-related risk factors for relapse. *MRD positivity defined at >0.01%. AUC, area under the curve; AYA, adolescent and young adult; BCA, B-cell aplasia; CAR-T, chimeric antigen receptor T-cell therapy; FCM, flow cytometry; HSCT, haematopoietic stem cell transplantation; KMT2A, lysine methyltransferase 2A; MRD, minimal residual disease; NGS, next-generation sequencing; OOS, out of specification; PCR, polymerase chain reaction.