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. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: ACS Chem Neurosci. 2021 Dec 2;12(24):4524–4534. doi: 10.1021/acschemneuro.1c00557

Table 5.

Rat Plasma Protein and Brain Homogenate Binding and Rat IV PBL Cassette Data

rat in vitro PPB/BHB and rat IV cassette PBL
compound number rat PPB (fu) rat BHB (fu) plasma (ng/mL) brain (ng/g) K p K p,uu
(S)-17l 0.001 0.001 30.9 16 0.52 0.52
(S)-17i 0.004 0.002 15.7 37.8 2.41 1.2
(S)-19a 0.022 0.005 9.21 20.4 2.22 0.5
(S)-19d 0.017 0.004 10.9 46.1 4.23 1.0