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. Author manuscript; available in PMC: 2022 Dec 15.
Published in final edited form as: ACS Chem Neurosci. 2021 Dec 2;12(24):4524–4534. doi: 10.1021/acschemneuro.1c00557

Table 6.

Mouse In Vitro and In Vivo DMPK Profiles

mouse in vitro CLhep and IV cassette PK
compound number predicted CLhep CLp (mL/min/kg) t1/2 (h) Vss (L/kg) Cmax (ng/mL)
(S)-17l 79.7 58 0.70 2.2 153
(S)-17i 87.1 111 0.71 5.3 45
(S)-19a 87.6 230 0.29 4.9 43
(S)-19d 88.1 268 0.18 3.8 58