Table 3.
Bonferroni Significant Differentially Methylated CpGs associated with a 1 μg/m3 increase in past year PM2.5 Exposure.
| CpG | chr | Average % Methylation | Regression Coefficient (M value) | % Diff in DNAm (Beta) | P value | Gene/Closest gene | Relation_to_Island |
|---|---|---|---|---|---|---|---|
| cg26210521 | chr4 | 88.6 | −0.256 | −1.70 | 3.08E-13 | SLC2A9 | OpenSea |
| cg20396870 | chr20 | 66.5 | −0.182 | −2.74 | 5.53E-13 | MACROD2 | OpenSea |
| cg12120973 | chr1 | 87.3 | −0.203 | −1.44 | 3.03E-11 | SCNN1D | OpenSea |
| cg22118655 | chr22 | 11.1 | 0.226 | 1.47 | 3.29E-10 | ELFN2 | Island |
| cg01108434 | chr8 | 86.9 | −0.254 | −1.96 | 1.42E-10 | PAG1 | OpenSea |
| cg07769732 | chr2 | 81.8 | − 0.169 | −1.69 | 3.92E-10 | KIDINS220 | N_Shore |
| cg09969776 | chr17 | 93.8 | −0.186 | −0.72 | 6.32E-10 | VPS53 | OpenSea |
| cg13388025 | chr1 | 84.1 | −0.162 | −1.40 | 1.98E-09 | ATAD3C | N_Shelf |
| cg02180798 | chr9 | 83.6 | −0.141 | −1.28 | 6.91E-09 | SHB | OpenSea |
| cg07582070 | chr6 | 85.7 | −0.140 | −1.13 | 7.33E-09 | IMPG1 | OpenSea |
| cg18168844 | chr5 | 13.4 | 0.253 | 2.60 | 5.76E-08 | EMB | N_Shelf |
| cg08163906 | chr14 | 9.4 | 0.288 | 1.76 | 6.17E-08 | PPP2R5C | Island |
| cg13315471 | chr2 | 74.6 | −0.121 | −1.55 | 1.02E-08 | TMEM214 | S_Shelf |
| cg23369179 | chr4 | 74.0 | −0.104 | −1.34 | 1.03E-08 | DCHS2 | OpenSea |
| cg05103574 | chr1 | 90.4 | −0.116 | −0.67 | 5.84E-08 | MECR | N_Shore |
| cg04351903 | chr1 | 14.4 | −0.116 | −0.96 | 2.46E-08 | LGR6 | OpenSea |
| cg06118847 | chr17 | 78.7 | −0.108 | −1.21 | 2.48E-08 | WSB1 | N_Shore |
| cg01219087 | chr20 | 87.2 | −0.152 | −1.11 | 2.53E-08 | PNRP | Island |
| cg17608529 | chr10 | 96.9 | −0.084 | −0.16 | 4.12E-08 | DIP2C | Island |
| cg10495669 | chr20 | 9.0 | 0.319 | 1.74 | 4.69E-08 | RBCK1 |