Table 1.
Patient characteristics.
| Variable | Control group (n=30) | TRT >1 year (n=33) | Total (n=63) | p value |
|---|---|---|---|---|
| Age (years) | 45±12.2 | 49.1±11.5 | 47.2±11.9 | 0.18 |
| Height (m) | 1.77±0.06 | 1.76±0.07 | 1.76±0.07 | 0.60 |
| Weight (kg) | 101.1±23.2 | 95.8±17.5 | 98.3±20.4 | 0.45 |
| BMI (kg/m2) | 31.9±6.3 | 30.9±5.6 | 31.4±5.93 | 0.54 |
| SBP (mmHg) | 136.7±22.4 | 127.1±14.9 | 131.7±19.3 | 0.04 |
| DBP (mmHg) | 91.2±16.1 | 83.5±10.0 | 87.1±13.7 | 0.02 |
| Smoker | 4 (13.3%) | 4 (13.3%) | 8 (12.7%) | 0.88 |
| Hypertense | 24 (80%) | 7 (21.2%) | 31 (49.2%) | <0.001 |
| Diabetic | 7 (23.3%) | 3 (9.1%) | 10 (15.9%) | 0.53 |
| TRT duration (months) | 4.2 (±3.5) | 28.8 (±13.3) | 17.1 (±15.8) | <0.001 |
| Haemoglobin (g/dL) | 14.8±1.6 | 15.6±13 | 15.2±1.5 | 0.06 |
| LDL (mg/dL) | 111.6±29.6 | 97.8±40.5 | 104.4±36.1 | 0.08 |
| Cholesterol (mg/dL) | 181.7±33.5 | 170.5±46.9 | 175.9±41.1 | 0.20 |
| HDL (mg/dL) | 38.2±7.1 | 44.3±14.2 | 41.4±11.7 | 0.049 |
| Glycemia (mg/dL) | 102±16.7 | 100±22.2 | 100.9±19.7 | 0.23 |
| HbA1c (%) | 6.26±2.6 | 6.0±1.5 | 6.1±2.1 | 0.86 |
| CRP (mg/dL) | 3.8±5.8 | 1.7±2.8 | 2.7±4.6 | 0.003 |
| Adiponectin (μg/mL) | 5.8±2.3 | 5.5±4.9 | 5.7±3.9 | 0.11 |
| TT (ng/dL) | 282.5±152.9 | 493.9±287.1 | 393.2±254.5 | <0.001 |
| LH (mUI/mL) | 3.5±2.7 | 1.5±1.7 | 2.5±2.4 | <0.001 |
| FSH (mUI/mL) | 4.8±6.0 | 3.0±3.8 | 3.9±5.0 | 0.01 |
| SHBG (nmol/L) | 21.5±7.6 | 28.9±26.4 | 25.4±20.0 | 0.09 |
| Prolactin (ng/mL) | 9.7±4.4 | 8.9±4.0 | 9.3±4.2 | 0.43 |
| Cortisol (μg/dL) | 11.4±4.3 | 12.6±4.6 | 12.1±4.5 | 0.27 |
| TSH (UI/mL) | 2.3±1.2 | 2.3±1.7 | 2.3±1.5 | 0.44 |
| Total PSA (ng/mL) | 0.57±0.34 | 1.07±0.85 | 0.83±0.70 | 0.02 |
Data are presented as mean (±standard deviation) and frequency (valid percentage); p values refer to Mann–Whitney U tests (continuous) and χ2 tests (categorical).
BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL, low-density lipoprotein; HDL, high-density lipoprotein; CRP, C-reactive protein; TT, total testosterone; LH, luteinizing hormone; SHBG, sex hormone-binding globulin; TSH, thyroid-stimulating hormone; PSA, prostate-specific antigen.