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. 2022 Jan 19;92(6):e2021543. doi: 10.23750/abm.v92i6.11991

Table 1.

CDC case definition (from ref. 6)

All 4 criteria must be met:
1. Age <21 years
2. Clinical presentation of MIS-C, including:
  • Fever: equal or > to 24 h

  • Laboratory evidence of inflammation

  • Multisystem involvement equal or > to 2 organ systems

  • Sever illness requiring hospitalization

3. No alternative plausible diagnosis
4. Evidence of recent SAR-CoV-2 infection/exposure:
  • Positive SARS-CoV-2 (RT-PCR)

  • Positive serology

  • Positive antigen test

  • COVID-19 exposure within 4 weeks prior to the onset of symptoms