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. 2022 Jan 5;12:807256. doi: 10.3389/fphar.2021.807256

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Copyright © 2022 Suvorov, Gupalova, Desheva, Kramskaya, Bormotova, Koroleva, Kopteva and Leontieva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune response induced by immunization of animals with recombinant protein SarsS. (A) Mice (n = 10) were immunized twice subcutaneously with the recombinant protein SarsS together with aluminum hydroxide as adjuvant. Control mice (n = 10) received aluminum hydrochloride as an adjuvant. Antibody titer was determined by ELISA as described in Western Blotting. (B) Rabbits (n = 3) were immunized three times subcutaneously with the recombinant protein SarsS together with aluminum hydroxide as vaccine adjuvant. Control rabbits (n = 2) received aluminum hydrochloride as an adjuvant. Antibody titer was determined by ELISA as described in ELISA Assay. Reciprocal antibody titers were characterized as log10 (ELISA) and presented as mean ± SEM. The p-values are obtained after comparison with control animals. Data were analyzed using the Student’s t-test * - p < 0.05.