Table 2.
Adverse events among all randomized participants
| Adverse Event | Curcumin | Placebo |
|---|---|---|
| Related or possibly related | ||
| Flatulence, constipation, diarrhea, or nausea | 7 | 7 |
| Headache | 1 | 1 |
| Warming or redness of face | 2 | |
| Tingling of tongue/mouth | 2 | |
| Dry mouth | 1 | |
| Skin irritation | 1 | |
| Eye redness, dryness, or swelling | 2 | |
| Likely or definitely unrelated | ||
| Orthopedic injury | 3 | |
| Mildly elevated LFTs | 2 | |
| Fever | 3 | |
| Kidney infection | 1 | 2 |
| Urinary tract infection | 2 | 1 |
| Upper respiratory infection | 5 | |
| IBS, worsening or incident | 2 | |
| COVID-19 infection | 2 | |
| Sore throat | 2 | |
| Tonsillitis, tonsil infection, or tonsillectomy | 1 | 1 |
| Hand, foot, and mouth | 1 | |
| Streptococcal pharyngitis | 1 | |
| Ear infection | 1 | |
| Numbness in extremities | 1 | |
| Emesis | 2 | |
| Influenza | 1 | |
| Lightheadedness | 1 | |
| Osteomyelitis | 1 | |
| Giardia infection | 1 | |
| Conjunctivitis | 1 | |
| Cholecystectomy surgery | 1 | |
| Iron deficiency | 1 | |
| Flank pain | 1 | |
| Abdominal and pelvic pain | 1 | |
| Sinus infection | 1 | |
| Strabismus surgery | 1 | |
| Yeast infection | 1 | |
| Root canal | 1 | |
Data are n, including participants who discontinued participation. LFT, liver function tests; IBS, irritable bowel syndrome; COVID-19, coronavirus disease 2019.