Table 3.
Associations of clinical characteristics with health-related quality of life adjusted for confounders
| Clinical Characteristic | Physical Component Summary | Mental Component Summary | ||||
|---|---|---|---|---|---|---|
| Women | Men | P Value for Interaction | Women | Men | P Value for Interaction | |
| eGFR, per 5 ml/min per 1.73 m2, at 10 ml/min per 1.73 m2 | ||||||
| Crude | 0.4 (–2.0 to 2.9) | 4.7 (3.2 to 6.2) | <0.001 | 2.9 (0.3 to 5.5) | 5.6 (4.0 to 7.2) | 0.09 |
| Adjusted | 0.6 (–1.8 to 3.1) | 4.8 (3.3 to 6.3) | <0.001 | 2.3 (–0.4 to 4.9) | 5.0 (3.4 to 6.7) | 0.08 |
| eGFR, per 5 ml/min per 1.73 m2, at 20 ml/min per 1.73 m2 | ||||||
| Crude | 0.8 (–0.4 to 2.0) | −0.2 (–1.1 to 0.8) | 0.23 | 0.7 (–0.6 to 2.0) | −0.1 (–1.1 to 0.9) | 0.31 |
| Adjusted | 1.1 (0.0 to 2.4) | −0.1 (–1.0 to 0.9) | 0.11 | 0.8 (–0.5 to 2.1) | −0.1 (–1.1 to 0.9) | 0.27 |
| Hemoglobin, per g/dl | ||||||
| Crude | 0.7 (0.1 to 1.4) | 1.5 (1.1 to 1.9) | 0.05 | 0.9 (0.3 to 1.6) | 1.9 (1.4 to 2.3) | 0.02 |
| Adjusted | 0.6 (–0.1 to 1.2) | 1.3 (0.9 to 1.7) | 0.07 | 0.7 (0.0 to 1.4) | 1.7 (1.2 to 2.1) | 0.02 |
| Phosphate, per mg/dl | ||||||
| Crude | 0.8 (–0.1 to 1.6) | −1.5 (–2.1 to –0.9) | <0.001 | 0.2 (–0.7 to 1.2) | −2.0 (–2.6 to –1.4) | <0.001 |
| Adjusted | 0.9 (0 to 1.7) | −1.3 (–1.9 to –0.7) | <0.001 | 0.5 (–0.5 to 1.4) | −1.7 (–2.4 to –1.1) | <0.001 |
| Systolic BP, per 10 mm Hg | ||||||
| Crude | −0.2 (–0.6 to 0.2) | 0.4 (0.1 to 0.7) | 0.02 | 0.0 (–0.4 to 0.5) | 0.4 (0.0 to 0.7) | 0.21 |
| Adjusted | 0.0 (–0.4 to 0.4) | 0.5 (0.2 to 0.8) | 0.03 | 0.1 (–0.3 to 0.6) | 0.4 (0.1 to 0.8) | 0.22 |
| Cholesterol, per 25 mg/dl, at 100 mg/dl | ||||||
| Crude | 1.3 (0.1 to 2.4) | 1.2 (0.5 to 1.9) | 0.86 | 1.7 (0.4 to 2.9) | 1.4 (0.6 to 2.2) | 0.73 |
| Adjusted | 1.0 (–0.1 to 2.1) | 1.0 (0.3 to 1.7) | 0.96 | 1.5 (0.3 to 2.7) | 1.2 (0.4 to 2.0) | 0.71 |
| Cholesterol, per 25 mg/dl, at 200 mg/dl | ||||||
| Crude | 0.1 (–0.3 to 0.5) | 0.4 (0.1 to 0.8) | 0.16 | 0.6 (0.1 to 1.0) | 0.7 (0.4 to 1.1) | 0.54 |
| Adjusted | 0.0 (–0.4 to 0.4) | 0.4 (0.0 to 0.7) | 0.14 | 0.5 (0.0 to 0.9) | 0.6 (0.3 to 1.0) | 0.54 |
| Diabetes, present versus absent | ||||||
| Crude | −4.2 (–7.5 to –0.9) | −7.6 (–10.0 to –5.3) | 0.10 | −1.7 (–5.1 to 1.8) | −6.8 (–9.1 to –4.4) | 0.02 |
| Adjusted | −2.6 (–6.0 to 0.8) | −6.9 (–9.5 to –4.3) | 0.03 | −0.1 (–3.7 to 3.6) | −6.1 (–8.9 to –3.3) | <0.001 |
| Peripheral vascular disease, present versus absent | ||||||
| Crude | −4.2 (–8.8 to 0.5) | −6.5 (–9.4 to –3.6) | 0.40 | 0.05 | ||
| Adjusted | −3.7 (–8.1 to 0.8) | −5.0 (–7.8 to –2.2) | 0.61 | −1.0 (–5.7 to 3.8) | −5.7 (–8.7 to –2.6) | 0.10 |
| Myocardial infarction, present versus absent | ||||||
| Crude | −9.3 (–14.3 to –4.4) | −4.1 (–7.0 to –1.2) | 0.07 | −6.9 (–12.1 to –1.8) | −3.9 (–6.9 to –0.9) | 0.32 |
| Adjusted | −4.4 (–9.1 to 0.3) | 0.4 (–2.4 to 3.2) | 0.08 | −3.3 (–8.4 to 1.8) | −0.5 (–3.5 to 2.6) | 0.34 |
The model for eGFR was adjusted for demographic covariates, medication covariates, BP, hemoglobin, smoking status, calcium, cholesterol, PO4, potassium, UACR, and comorbidity covariates. The model for hemoglobin was adjusted for age, hyper-polypharmacy, smoking status, and kidney function covariates. The model for serum PO4 was adjusted for age, educational level, marital status, children, hyper-polypharmacy, smoking status, and kidney function covariates. The model for systolic BP was adjusted for demographic covariates, medication covariates, cardiovascular covariates, blood chemistry covariates, and comorbidity covariates (except hypertension). The model for cholesterol was adjusted for demographic covariates, hyper-polypharmacy, smoking status, albumin, and diabetes. The model for diabetes was adjusted for demographic covariates, medication covariates, and smoking status. The model for peripheral vascular disease was adjusted for demographic covariates, BP, smoking status, calcium, cholesterol, PO4, kidney function covariates, and comorbidity covariates. The model for myocardial infarction was adjusted for demographic covariates, cardiovascular covariates, calcium, cholesterol, PO4, potassium, kidney function covariates, and comorbidity covariates. Because of the nonlinear relationship with health-related quality of life, the associations for both eGFR and serum cholesterol are presented at varying values. PO4, phosphate; UACR, urine albumin-creatinine ratio.