Table 2.

Associations of doubling in baseline TNF receptor-1, TNF receptor-2, kidney injury molecule-1, urinary albumin-creatinine ratio, and eGFR with the kidney outcome in patients with normoalbuminuria

Biomarker	n/N	Hazard Ratio (95% Confidence Interval)
		Model 1	Model 2	Model 3	Model 4
TNFR-1	51/2553	2.89 (1.52 to 5.50)	2.07 (1.04 to 4.15)	4.07 (1.85 to 8.98)	4.18 (1.81 to 9.64)
TNFR-2	51/2553	2.05 (1.40 to 3.01)	1.92 (1.13 to 3.26)	2.13 (1.46 to 3.10)	2.35 (1.51 to 3.65)
KIM-1	51/2553	1.42 (1.06 to 1.91)	1.32 (0.96 to 1.81)	1.36 (1.00 to 1.86)	1.36 (0.98 to 1.88)
UACR	51/2553	1.39 (1.01 to 1.91)	1.26 (0.90 to 1.75)	1.39 (1.01 to 1.91)	1.25 (0.89 to 1.74)
eGFR	51/2553	0.93 (0.40 to 2.17)	2.39 (0.84 to 6.78)	0.93 (0.40 to 2.16)	2.33 (0.82 to 6.59)

Models are adjusted for the following covariates. Model 1 was adjusted for treatment allocation. Model 2 was adjusted for treatment allocation as well as age, sex, race, body mass index, history of cardiovascular disease, systolic BP, diastolic BP, LDL cholesterol, and glycated hemoglobin. Model 3 was adjusted for treatment allocation as well as UACR and eGFR. Model 4 was adjusted for all covariates in models 2 and 3. When analyzing the association of UACR or eGFR with the outcome, models 3 and 4 are not adjusted for UACR and eGFR, respectively. TNFR-1, TNFR-2, KIM-1, and UACR are log transformed for the analysis. TNFR-1, TNF receptor-1; TNFR-2, TNF receptor-2; KIM-1, kidney injury molecule-1; UACR, urinary albumin-creatinine ratio.