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. 2022 Feb 8;30(3):388–399.e3. doi: 10.1016/j.chom.2022.02.003

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SARS-CoV-2-specific CD4+ and CD8+ T cell responses in the study groups

SARS-CoV-2-specific CD4+ and CD8+ T cell responses were measured as percentages of AIM+ (OX40+CD137+) CD4+ T cells (A and B) or AIM+ (CD69+CD137+) CD8+ T cells (C and D) after stimulation of PBMCs with peptides pools encompassing spike-only (Spike) MPs or the experimentally defined CD4RE and CD8RE MPs representing all the proteome without spike. EVB MP was used as a control. Graphs show individual response of spike, CD4RE, or CD8RE and the combination of both (total CD4+ or total CD8+) plotted as background subtracted (A and C) or as SI (B and D) against DMSO negative control. Geometric mean with standard deviation (SD) for the 4 different groups is shown. Kruskal-Wallis test adjusted with Dunn’s test for multiple comparisons was performed, and p values < 0.05 considered statistically significant. I−V−, unexposed and unvaccinated (n = 30); I+V−, infected and non-vaccinated (n = 30); I+V+, infected and then vaccinated (n = 30); I−V+, non-infected and vaccinated (n = 30). Threshold of positivity (TP) is indicated. Median response and the number or percentage of positive responding donors for each group is shown.