Table 1.
Description of donor cohort characteristics and demographics
| Cohort name | I−V− | I+V− | I−V+ | I+V+ | V+I+ | |
|---|---|---|---|---|---|---|
| number of donors | 50 | 50 | 66 | 50 | 23 | |
| gender (M/F) | (26, 24) | (21, 29) | (28, 38) | (23, 27) | (7, 16) | |
| median age (years) | 25 (17–64) | 42 (19–67) | 40 (21–74) | 38 (21–73) | 30 (22–68) | |
| race | white (n [%]) | 32 (64%) | 37 (74%) | 38 (58%) | 39 (78%) | 15 (65%) |
| Hispanic/Latino (n [%]) | 8 (16%) | 7 (14%) | 11 (17%) | 6 (12%) | 5 (22%) | |
| Asian (n [%]) | 8 (16%) | 4 (8%) | 16 (24%) | 3 (6%) | 3 (13%) | |
| Black (n [%]) | 2 (4%) | 2 (4%) | 2 (3%) | 2 (4%) | 0 (0%) | |
| sample collection date | 2013–2019 | 2020–2021 | 2021 | 2021 | 2021 | |
| COVID-19 vaccination status | none | none | vaccinated | vaccinated | vaccinated | |
| Pfizer (n [%]) | – | – | 30 (45%) | 25 (50%) | 15 (65%) | |
| Moderna (n [%]) | – | – | 36 (55%) | 25 (50%) | 8 (35%) | |
| days from second dose of vaccination | – | – | 16 (13–190) | 32 (7–188) | 163(55–271) | |
| SARS-CoV-2 status | Ab(−) | Ab(+) or PCR(+) | Ab(+) and PCR(−) | Ab(+) or PCR(+) | PCR(+) | |
| SARS-CoV-2 PCR (n [%]) | positive | 0 (0%) | 47 (94%) | 0 (0%) | 45 (90%) | 23 (100%) |
| unknown | – | 3 (6%) | – | 5 (10%) | – | |
| spike (S) antibody response (n [%]) | median | 3.0 | 191.8 | 4,157.0 | 4,654.0 | 8,783.0 |
| range | 3.0–23.9 | 3.0–7,326.0 | 410.6–3,2033.0 | 159.2–2,5876.0 | 2,165.0–3,5319.0 | |
| nucleocapsid (N) antibody response (n [%]) | median | 4.9 | 177.9 | 16.3 | 73.2 | 241.5 |
| range | 3.0–339.8 | 3.0–11755.0 | 3.0–109.0 | 3.0–1873.0 | 72.6–5044.0 | |
| post-symptom onset (days) | median | – | 119 | – | 354 | 32 |
| range | – | 20–308 | – | 57–508 | 18–93 | |
| symptoms (n [%]) | asymptomatic | – | 0 (0%) | – | 0 (0%) | 0 (0%) |
| mild | – | 44 (88%) | – | 45 (90%) | 23 (100%) | |
| moderate | – | 3 (6%) | – | 3 (6%) | 0 (0%) | |
| severe | – | 3 (6%) | – | 2 (4%) | 0 (0%) | |
Summary of donor characteristics: non-infected, non-vaccinated, I−V−; infected and non-vaccinated, I+V−; infected and then vaccinated, I+V+; non-infected and vaccinated, I−V+; and vaccinated and then infected, V+I+.