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PFD attenuates TGF-β signaling in renal cancer cells.
(A) and (B) PFD suppresses TGF-β-induced Smad phosphorylation. Phosphorylation of Smad2/3 was detected by Western blot in 786-O and ACHN cells in the presence of TGF-β or PFD. (C) and (D) PFD suppresses TGF-β-induced Ski degradation. Western blot analysis for the protein expression of Ski in 786-O and ACHN cells. Data represents the means ± SD. *P < .05; **P < .01; ***P < .001.
