Figure 3.

Correlation analysis between circulating microbiome, gut-permeability markers, inflammatory cytokines and clinical parameters of cirrhosis severity.

a) Spearman’s rank correlation coefficients between abundances of different genera, inflammatory cytokines (LPS, IL-6 and IL-8) and gut permeability markers (FABP2) in hepatic vein blood b) – in peripheral vein blood of patients with cirrhosis. c) Spearman’s rank correlation coefficients between abundances of different genera and cirrhosis parameters in hepatic vein blood; d) – in peripheral vein blood of patients with cirrhosis. Genera are presented on the x-axis, whereas inflammatory cytokines, gut permeability markers and clinical parameters of cirrhosis are presented on the y-axis. Colors represent the Spearman rank correlation coefficients at P value < .05, while numbers – at Benjamini–Hochberg corrected P value < .05. Circles without correlation coefficients did not withstand multiple corrections. Abbreviations: HVPG – hepatic venous pressure gradient; CHILD – Child-Turcotte-Pugh; MELD – Model for End-Stage Liver Disease