Table 1.
The demographic data of all AD patients.
| Exacerbated AD patients (n = 60) |
Non-exacerbated AD patients (n = 40) |
P | |
|---|---|---|---|
| Sex | |||
| Male | 23 (38.3%) | 20 (50%) | 0.248 |
| Female | 37 (61.7%) | 20 (50%) | |
| Age (years) Mean ± SD | 42.217 ± 14.713 | 51.300 ± 18.622 | 0.012 |
| Marital status | |||
| Single | 23 (38.3%) | 7 (17.5%) | 0.026 |
| Married | 37 (61.7%) | 33 (82.5%) | |
| Educational level | |||
| Diploma or lower | 9 (15%) | 15 (37.5%) | 0.007 |
| B.Sc./B.A. | 32 (53.3%) | 21 (52.5%) | |
| MSc, MD, Ph.D. or higher | 19 (31.7%) | 4 (10%) | |
| History of alcohol consumption | |||
| Yes | 3 (5%) | 1 (2.5%) | 0.532 |
| No | 57 (95%) | 39 (97.5%) | |
| History of smoking cigarette | |||
| Yes | 3 (5%) | 4 (10%) | 0.337 |
| No | 57 (95%) | 36 (90%) | |
| Familial history of Eczema | |||
| Yes | 29 (48.3%) | 7 (17.5%) | 0.002 |
| No | 31 (51.7%) | 33 (82.5%) | |
| Chronic comorbiditiesa | |||
| Yes | 39 (65%) | 21 (52.5%) | 0.211 |
| No | 21 (35%) | 19 (47.5%) | |
| History of food/drug allergy | |||
| Yes | 38 (63.3%) | 25 (62.5%) | 0.933 |
| No | 22 (36.7%) | 15 (37.5%) | |
| Topical treatment | |||
| Topical corticosteroids | 2 (3.3%) | 5 (12.5%) | 0.030 |
| Eucerin/vaseline | 1 (1.7%) | 4 (10%) | |
| More than 1 topicalb including steroids | 50 (83.3%) | 30 (75%) | |
| More than 1 topical without steroids | 7 (11.7%) | 1 (2.5%) | |
| Phototherapy | |||
| Yes | 33 (55%) | 11 (27.5%) | 0.007 |
| No | 27 (45%) | 29 (72.5%) | |
| Systemic treatment | |||
| Immunosuppressive medicationc | 29 (48.3%) | 12 (30%) | 0.001 |
| Antihistamine | 6 (10%) | 17 (42.5%) | |
| No | 25 (41.7%) | 11 (27.5%) | |
| Phototherapy discontinuation | |||
| Yes | 52 (86.7%) | 32 (80%) | 0.373 |
| No | 8 (13.3%) | 8 (20%) | |
| Treatment discontinuation | |||
| Yes | 17 (28.3%) | 4 (10%) | 0.027 |
| No | 43 (71.7%) | 36 (90%) | |
| Treatment dose alteration | |||
| Yes, increased | 11 (18.3%) | 1 (2.5%) | <0.001 |
| Yes, decreased | 22 (36.7%) | 0 (0%) | |
| No | 27 (45%) | 39 (97.5%) | |
| The disease duration (years) Mean ± SD | 12.567 ± 8.472 | 7.225 ± 6.224 | <0.001 |
| Self-quarantine | |||
| No | 3 (5%) | 7 (17.5%) | <0.001 |
| Most times | 22 (36.7%) | 32 (80%) | |
| Always | 35 (58.3%) | 1 (2.5%) | |
| Handwashing (more than 10 times/day) | |||
| No | 2 (3.3%) | 5 (12.5%) | <0.001 |
| Most times | 10 (16.7%) | 30 (75%) | |
| Always | 48 (80%) | 5 (12.5%) | |
| Hand disinfection | |||
| Yes | 49 (81.7%) | 17 (42.5%) | <0.001 |
| No | 11 (18.3%) | 23 (57.5%) | |
| Surface disinfection | |||
| Yes | 4 (6.7%) | 10 (25%) | 0.010 |
| No | 56 (93.3%) | 30 (75%) | |
| History of COVID-19 infection | |||
| Yes | 3 (5%) | 0 (0%) | 0.151 |
| No | 57 (95%) | 40 (100%) | |
| POEM scoring | |||
| Silent | 1 (1.7%) | 12 (30%) | <0.001 |
| Mild | 10 (16.7%) | 16 (40%) | |
| Moderate | 46 (76.7%) | 12 (30%) | |
| Severe | 3 (5%) | 0 (0%) | |
| Very severe | 0 (0%) | 0 (0%) | |
| The Corona disease anxiety scale Mean ± SD | 6.883 ± 5.696 | 10.775 ± 6.154 | 0.001 |
Abbreviations: atopic dermatitis, AD; Bachelor of Arts, B.A.; Bachelor of Science, B.Sc.; coronavirus disease 2019, COVID-19; Master of Science, MSc; medical doctor, MD; number, n; doctoral degree, Ph.D.
a
Chronic comorbidities: cardiovascular diseases, diabetes mellitus, hypertension, hyperlipidemia, pulmonary diseases, thyroid disease, cancer, and others.
b
More than 1 topical: Eucerin/vaseline, calcineurin inhibitors.
c
Immunosuppressive medications: azathioprine, cyclosporine, methotrexate, prednisolone, more than one immunosuppressive medication, others.