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Schematic representation of a lipid–polymer hybrid nanoparticles (NPs). The NPs comprise a polymeric core containing a payload (siRNA or ASOs) surrounded by a lipid shell. Note that an additional outer PEG layer can be added and conjugated with targeting moieties such as aptamers, peptides, antibodies, and lipophilic derivatives (e.g., cholesterol). PEG, polyethylene glycol.
