Table 3. Cationic Lipids That Have Been Used in Lipid-Based NPsa.
| amino lipid | optimized ionizable lipid | lipidoid |
|---|---|---|
| Monovalent cationic: DOTAP; DOTMA; DMRIE | Dlin-DMA | C12-200 |
| Monovalent ionizable: DODAP; DODMA | Dlin-KC2-DMA | 98N12-5 |
| Multivalent ionizable: DOGS | Dlin-MC3-DMA | |
| Cholesterol derivatives: DC-Chol; GL67 |
a
Abbreviations: DC-Chol, 3β-(N-(N′,N′-dimethylaminoethane)carbamoyl)cholesterol; DLinDMA, 1,2-dilinoleyloxy-3-dimethylaminopropane; DMRIE, N-(2-hydroxyethyl)-N,N-dimethyl-2,3-bis(tetradecyloxy)-1-propanaminium bromide; DODAP, 1,2-dioleoyl-3-dimethylammoniumpropane; DODMA, 1,2-dioleyloxy-3-dimethylaminopropane; DOGS, N,N-dioctadecylamidoglycylspermine; DOTAP, N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl sulfate; DOTMA, N-[1-(2,3-dioleyloxy)propyl])-N,N,N-trimethylammonium chloride; GL-67, N4-spermine cholesterylcarbamate