TABLE 7.

Most frequent ADRs of three types of mAb.

Types of mAbs (n,%)	Most frequent ADRs of this type (top 5)	No.(%)
Chimeric antibodies
Rituximab(130,22.61)	Rash	35 (20.83)
Cetuximab(38,6.61)	Chills	22 (13.10)
	Fever	18 (10.71)
	Dyspnea	17 (10.12)
	Myelosuppression	12 (7.14)
Humanized antibodies
Trastuzumab(171, 29.74)	Fever	44(12.46)
Bevacizumab(77,13.39)	Chills	39(11.05)
Camrelizumab(60,10.43)	Myelosuppression	33(9.35)
Toripalimab(15,2.61)	Vomiting	23(6.52)
Pembrolizumab(10,1.74)	Nausea	22(6.23)
Pertuzumab(9,1.57)
Nimotuzumab(7,1.22)
Tislelizumab(2,0.35)
Atezolizumab(1,0.17)
Tocilizumab(1,0.17)
Fully human antibodies
Sintilimab(48,8.35)	Rash	10(18.52)
Evolocumab(3,0.52)	Fever	5(9.26)
Nivolumab(2,0.35)	Nausea	4(7.41)
Adalimumab(1,0.17)	Hyperthyroidism	4(7.41)
	Hepatic failure	3(5.56)