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. 2022 Jan 25;12:760013. doi: 10.3389/fphar.2021.760013

TABLE 9.

Signals of ADRs.

Drug ADR ROR 95% CI lower limit PRR 95% CI lower limit χ2
Pembrolizumab Pneumonitis 39.93 8.28 28.25 8.77 104632.48
Rituximab Urticaria 10.49 1.08 10.27 1.09 16193.88
Sintilimab Hepatic failure a 6.96 1.61 6.59 1.62 9109.80
Sintilimab Hyperthyroidism 9.49 2.46 8.78 2.48 6804.49
Camrelizumab Hyperthyroidism 7.74 2.02 7.27 2.03 5081.48
Camrelizumab Pneumonitis 4.74 1.15 4.54 1.16 5049.10
Camrelizumab Hypothyroidism 9.87 2.76 9.09 2.79 3780.48
Bevacizumab Hypertension 12.35 3.53 11.32 3.55 1691.69
Nimotuzumab Fever 5.91 1.29 3.80 1.50 457.11
Bevacizumab Vomiting 3.28 1.36 3.04 1.38 197.76
Trastuzumab Vomiting 2.27 1.01 2.18 1.03 73.28
Sintilimab Rash 2.63 1.23 2.29 1.26 42.36
Rituximab Dyspnea 5.15 2.30 4.67 2.33 22.22
Trastuzumab Chills 3.74 2.17 3.18 2.22 5.98
a

Off-label ADR.