Rate Parameter	Optimized Rate (WT)	Optimized rate (Scn4b-/-)	Rate Equations
a11_variable1	2.3989e-02;	2.0761e-02;	Where the transition rates are of the form:
a11_variable2	9.6108e + 02;	9.7685e + 02;
a12	8.5613e + 02;	8.3340e + 02;	a11= Tfactor*1/(Input(1)*exp(-V/Input(2)));
a13	7.2682e + 01;	6.1087e + 01;	a12= Input(3)*a11;
b11_variable1	1.7233e-01;	1.6995e-01;	a13= Input(4)*a11;
b11_variable2	1.9691e + 01;	1.8560e + 01;	b11= Tfactor*1/(Input(5)*exp(V/Input(6)));
b12	8.8549e + 01;	9.3042e + 01;	b12= Input(7)*b11;
b13	1.4841e + 02;	1.7914e + 02;	b13= Input(8)*b11;
a3_variable1	3.6734e-01;	3.9273e-01;	a3= Tfactor*Input(9)*exp(-V/Input(10));
a3_variable2	9.8034e + 02;	9.8807e + 02;	b3= Tfactor*Input(11)*exp((V)/Input(12));
b3_variable1	5.3241e + 01;	4.7402e + 01;	a2= Tfactor*(Input(13)*exp(V/Input(14)));
b3_variable2	1.4204e + 01;	1.3469e + 01;	b2= ((a13*a2*a3)/(b13*b3));
a2_variable1	8.7852e + 01;	8.1085e + 01;	a6= Tfactor*(Input(15)*exp(V/Input(16)));
a2_variable2	9.9972e + 02;	9.9984e + 02;	b6= Tfactor*Input(17)*exp(-V/Input(18));
a6_variable1	6.0921e + 02;	6.0756e + 02;
a6_variable2	8.6490e + 01;	7.8591e + 01;	a2s = Tfactor*(Input(19)*exp(V/Input(20)));
b6_variable1	1.5645e + 02;	1.6214e + 02;	b2s = Tfactor*(Input(21)*exp(-V/Input(22)));
b6_variable2	3.0317e + 01;	4.3656e + 01;	a3s = Tfactor*Input(23)*exp(-V/Input(24));
a2s_variable1	1.5817e + 01;	2.3130e + 01;	b3s = (a2s*a3s*a13)/(b2s*b13);
a2s_variable2	9.9982e + 02;	9.9969e + 02;
b2s_variable1	1.0010e-03;	1.0208e-03;	Q10 = 3; T = 295;
b2s_variable2	1.1963e + 01;	1.1383e + 01;	Tfactor = 1.0/(Q10^((37.0-(T-273))/10.0));
a3s_variable1	4.4773e-03;	2.8677e-03;
a3s_variable2	9.9993e + 02;	9.8330e + 02;	Note: b2, b3s are constrained by microscopic reversibility.