The results of RBMEM indicated the hierarchical distribution of metastasis to preselected brain regions relative to other primary cancers. Multinomial analysis was used to determine which of the preselected brain regions (frontal, parietal, temporal, and occipital lobes; cerebellum; and brainstem) were most likely to be metastasized from 5 primary cancers. A: Topographic results show that lung-to-brain metastasis was most likely to occur in the left frontal cortex, right parietal lobe, left parietal lobe, and left temporal lobe. B: Colon cancer demonstrated a distribution pattern similar to random and did not have dominant representation in any CNS location. C: Breast cancer had the highest probability of metastasis to the right and left cerebellar hemispheres. D: Renal cell carcinoma had the highest probability of metastasis to the brainstem. E: Melanoma had the highest probability of metastasis to the right frontal lobe and right occipital lobe relative to other tumor subtypes. F: Topographic illustration of the CNS showing the primary cancers with the highest probabilities of metastasis to stereotactic coordinates corresponding to the center of each neuroanatomical lobe. Figure is available in color online only.