The results of BRSM revealed that primary cancers, independent of each other, had defined topographic distributions of metastasis to specific brain regions. Using fitted models to generate prediction probabilities for these brain regions, we found that lung cancer (A) had the highest propensity to metastasize to the left and right temporal lobes, breast cancer (B) had the highest proclivity for metastasis to the right cerebellar hemisphere, melanoma (C) had the highest probability of metastasis to the left temporal lobe, colon cancer (D) had the highest probability of metastasis to the right cerebellar hemisphere, and renal cell carcinoma (E) had the highest predilection for spread to the brainstem. Figure is available in color online only.