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. 2022 Feb 8;3(3):e173–e183. doi: 10.1016/S2666-5247(21)00358-X

Figure 4.

Figure 4

Vaccine elicited T-cell responses to SARS-CoV-2 antigens

Antigen-specific T-cell responses on days 1 and 43 were measured by IFN-γ ELISPOT assay using PBMCs stimulated with overlapping peptides spanning the full length of the spike protein for GX-19 and the spike protein and nucleocapsid protein for GX-19N. Individual data points are shown as a dot plot with lines showing the mean with standard deviation. (A) Spike protein specific T-cell responses on days 1 and 43 in participants who received 1·5 mg (i) and 3·0 mg (ii) GX-19. (B) Sum of spike protein and nucleocapsid protein specific T-cell response in participants who received GX-19N. (C) Sum of spike protein and nucleocapsid protein specific (i), spike protein specific (ii), and nucleocapsid protein specific (iii) T-cell responses on days 1 and 43 in participants who received GX-19N. PBMCs=peripheral blood mononuclear cells. SFU=spot-forming-unit.