Table 1.
Descriptive statistics of demographic characteristics
| GX-19 1·5 mg group (n=20) | GX-19 3·0 mg group (n=20) | GX-19N 3·0 mg group (n=21) | Patients with COVID-19*(n=28) | Patients with COVID-19†(n=20) | Patients with COVID-19‡(n=6) | ||
|---|---|---|---|---|---|---|---|
| Sex | |||||||
| Male | 10 (50%) | 13 (65%) | 9 (43%) | 26 (93%) | 13 (65%) | 1 (17%) | |
| Female | 10 (50%) | 7 (35%) | 12 (57%) | 2 (7%) | 7 (35%) | 5 (83%) | |
| Ethnicity | |||||||
| Asian | 20 (100%) | 20 (100%) | 21 (100%) | 28 (100%) | 20 (100%) | 6 (100%) | |
| Age, years | 35·5 (7·7) | 37·3 (8·8) | 39·3 (8·3) | 42·6 (15·6) | 66·7 (10·7) | 65·2 (8·5) | |
| Baseline height, cm | 165·5 (7·0) | 169·3 (8·2) | 169·6 (7·0) | .. | .. | .. | |
| Baseline weight, kg | 66·9 (7·8) | 70·6 (11·6) | 67·8 (10·7) | .. | .. | .. | |
| Baseline BMI, kg/m2 | 24·4 (2·0) | 24·5 (2·3) | 23·6 (2·5) | 24·6 (1·8)§ | 24·1 (4·6)¶ | 27·1 (4·0)‖ | |
| Childbearing potential | 10 (50%) | 6 (30%) | 12 (57%) | 0 | 0 | 0 | |
| Smoking history | |||||||
| Non-smoker | 14 (70%) | 15 (75%) | 11 (52%) | .. | .. | .. | |
| Former smoker | 6 (30%) | 5 (25%) | 10 (48%) | .. | .. | .. | |
| Alcohol history | |||||||
| No | 11 (55%) | 11 (55%) | 3 (14%) | .. | .. | .. | |
| Ex-drinker** | 9 (45%) | 9 (45%) | 18 (86%) | .. | .. | .. | |
| No history of drug use | 20 (100%) | 20 (100%) | 21 (100%) | .. | .. | .. | |
| From COVID-19 diagnosis to sampling, days | .. | .. | .. | 59 (48–77) | 42 (39–50) | 32 (27–38) | |
| Score on ordinal scale†† | |||||||
| 4–5 | .. | .. | .. | 25 (89%) | 8 (40%) | 4 (67%) | |
| 6 | .. | .. | .. | 1 (4%) | 8 (40%) | 0 | |
| 7 | .. | .. | .. | 2 (7%) | 4 (20%) | 2 (33%) | |
Data are n (%), Mean (SD), or Median (IQR). BMI=body-mass index.
Convalescent patients with COVID-19 provided plasma for the comparison of neutralising response in the focus reduction neutralisation test.
Convalescent patients with COVID-19 provided plasma for the comparison of neutralising response in the pseudovirus neutralisation assay.
Convalescent patients with COVID-19 provided peripheral blood mononuclear cells for evaluating the T cell response in IFN-γ enzyme-linked immunosorbent spot assay.
n=four (14%) of 28 patients.
n=20 (100%) of 20 patients.
n=six (100%) of six patients.
Participants who had ever drank alcohol, but had stopped alcohol consumption at least 3 months before the study.
National Institute of Allergy and Infectious Diseases ordinal scale was used; the ordinal score is the patient's worst score during COVID-19; scores on the ordinal scale are as follows: 1=not hospitalised, no limitations of activities; 2=not hospitalised, limitation of activities, home oxygen requirement, or both; 3=hospitalised, not requiring supplemental oxygen and no longer requiring ongoing medical care (used if hospitalisation was extended for infection-control reasons); 4=hospitalised, not requiring supplemental oxygen but requiring ongoing medical care (COVID-19–related or other medical conditions); 5=hospitalised, requiring any supplemental oxygen; 6=hospitalised, requiring non-invasive ventilation or use of high-flow oxygen devices; and 7=hospitalised, receiving invasive mechanical ventilation or extracorporeal membrane oxygenation.