Table 3:

Summary table of bivariate categorical relationships comparing the highest and lowest quintiles oflast month cannabis × resin THC concentration × daily cannabis use interpolated

Anomaly	Total numbers of anomalies in quintile 5	Total numbers of normals in quintile 5	Total numbers of anomalies in Quintile 1	Total numbers of normals in quintile 1	RR	RR (Lower bound)	RR (upper bound)	AFE	AFE (lower bound)	AFE (upper bound)	PAR	PAR (lower bound)	PAR (upper bound)	Chi-squared	P-value	E-value esimate	E-value (95% lower bound)
Foetal alcohol	686	10 335 677	5	3 967 367	52.6610	21.8492	126.9237	0.9810	0.9542	0.9921	0.9739	0.9375	0.9891	251.5786	5.88E-57	104.82	43.19
Amniotic band	862	10 335 501	59	3 967 313	5.6078	4.3077	7.3002	0.8217	0.7679	0.8630	0.7690	0.7044	0.8196	209.0833	1.09E-47	10.69	8.08
Multicystic renal dys	6362	10 330 000	684	3 966 688	3.5700	3.2993	3.8630	0.7199	0.6969	0.7411	0.6500	0.6242	0.6741	1143.2133	6.70E-251	6.60	6.05
VATER/VACTERL	726	10 335 637	61	3 690 483	4.2494	3.2723	5.5182	0.7647	0.6944	0.8188	0.7054	0.6251	0.7685	139.8292	1.45E-32	7.97	6.00
Hypoplastic right ht	961	10 335 402	97	3 967 276	3.8027	3.0861	4.6856	0.7370	0.6760	0.7866	0.6695	0.6004	0.7266	182.0095	8.82E-42	7.07	5.62
Teratogenic synds	2000	10 334 363	219	3 967 154	3.5053	3.0489	4.0300	0.7147	0.6720	0.7519	0.6442	0.5965	0.6862	353.4852	3.69E-79	6.47	5.55
Hip dysplasia	11 179	10 325 184	1325	3 689 220	3.0124	2.8457	3.1889	0.6680	0.6486	0.6864	0.5972	0.5762	0.6172	1593.9238	0.00E + 00	5.47	5.14
Omphalocele	4163	10 332 199	562	3 966 810	2.8432	2.6035	3.1050	0.6483	0.6159	0.6779	0.5712	0.5366	0.6032	591.8580	4.94E-131	5.13	4.65
Valproate syndrome	72	10 336 290	4	3 967 368	6.9089	2.5243	18.9091	0.8553	0.6039	0.9471	0.8102	0.5075	0.9269	19.1507	6.04E-06	13.30	4.49
Edward syndrome	8773	10 327 590	1265	3 966 107	2.6619	2.5096	2.8235	0.6243	0.6015	0.6458	0.5457	0.5216	0.5685	1147.9334	6.31E-252	4.77	4.46
Matern infect malform	1134	10 335 229	147	3 967 225	2.9609	2.4935	3.5160	0.6623	0.5990	0.7156	0.5863	0.5183	0.6446	169.0136	6.08E-39	5.37	4.42
Patau syndrome	3186	10 333 177	457	3 966 915	2.6759	2.4260	2.9515	0.6263	0.5878	0.6612	0.5477	0.5072	0.5849	419.5932	1.50E-93	4.79	4.29
Ebstein’s anomaly	449	10 335 913	56	3 967 316	3.0775	2.3311	4.0628	0.6751	0.5710	0.7539	0.6002	0.4882	0.6877	69.8286	3.23E-17	5.61	4.09
Lateral anomalies	2900	10 333 462	405	3 690 140	2.5566	2.3042	2.8367	0.6089	0.5660	0.6475	0.5342	0.4898	0.5749	336.8852	1.52E-75	4.55	4.04
Genetic syndromes	9047	10 327 316	1435	3 965 937	2.4198	2.2888	2.5584	0.5868	0.5631	0.6091	0.5064	0.4821	0.5296	1032.5849	7.42E-227	4.27	4.01
Cystic lung	1210	10 335 153	176	3 967 196	2.6388	2.2529	3.0908	0.6210	0.5561	0.6765	0.5422	0.4744	0.6012	156.3959	3.47E-36	4.72	3.93
Situs inversus	1098	10 335 264	159	3 967 214	2.6506	2.2445	3.1302	0.6227	0.5545	0.6805	0.5440	0.4727	0.6056	142.7689	3.30E-33	4.74	3.92
Hydronephrosis	15 960	10 320 403	2758	3 964 614	2.2211	2.1332	2.3127	0.5498	0.5312	0.5676	0.4688	0.4502	0.4868	1580.8321	0.00E + 00	3.87	3.69
Posterior urethral valve	1700	10 334 662	277	3 967 096	2.3556	2.0747	2.6746	0.5755	0.5180	0.6261	0.4949	0.4366	0.5471	185.8450	1.28E-42	4.14	3.57
Severe microcephaly	4513	10 331 849	774	3 966 599	2.2380	2.0737	2.4153	0.5532	0.5178	0.5860	0.4722	0.4367	0.5054	452.6242	9.68E-101	3.90	3.57
Limb	55 575	10 280 787	9536	3 681 008	2.0808	2.0362	2.1265	0.5194	0.5089	0.5297	0.4433	0.4329	0.4536	4590.7979	0.00E + 00	3.58	3.49
Anencephalus and ∼	4844	10 331 519	860	3 966 512	2.1619	2.0107	2.3245	0.5374	0.5027	0.5698	0.4564	0.4219	0.4889	456.2601	1.57E-101	3.75	3.44
AVSD	4990	10 331 373	900	3 966 472	2.1281	1.9823	2.2846	0.5301	0.4955	0.5623	0.4491	0.4150	0.4812	456.1556	1.65E-101	3.68	3.38
Polydactyly	15 794	10 320 569	2964	3 964 408	2.0453	1.9666	2.1271	0.5111	0.4915	0.5299	0.4303	0.4112	0.4488	1334.9209	1.46E-292	3.51	3.35
Abdominal wall defx	6525	10 329 837	1234	3 966 138	2.0296	1.9098	2.1568	0.5073	0.4764	0.5364	0.4266	0.3965	0.4552	542.2794	3.01E-120	3.48	3.23
Urinary	48 201	10 288 162	9559	3 957 814	1.9354	1.8935	1.9783	0.4833	0.4719	0.4945	0.4033	0.3923	0.4141	3621.1633	0.00E + 00	3.28	3.19
Turner syndrome	2965	10 333 397	551	3 966 822	2.0654	1.8859	2.2620	0.5158	0.4698	0.5579	0.4350	0.3900	0.4767	255.4275	8.52E-58	3.55	3.18
Chromosomal	53 757	10 282 606	10 726	3 956 646	1.9237	1.8843	1.9639	0.4802	0.4693	0.4908	0.4003	0.3899	0.4106	3983.8113	0.00E + 00	3.26	3.18
Blader extr/epispad	809	10 335 554	144	3 967 229	2.1564	1.8061	2.5746	0.5363	0.4463	0.6116	0.4552	0.3668	0.5313	75.8075	1.56E-18	3.74	3.01
Club foot	14 653	10 321 710	2999	3 964 373	1.8754	1.8032	1.9505	0.4668	0.4454	0.4873	0.3875	0.3672	0.4071	1018.4416	8.81E-224	3.16	3.01
Hypoplastic left ht	2946	10 333 417	580	3 966 793	1.9496	1.7835	2.1311	0.4871	0.4393	0.5308	0.4069	0.3612	0.4495	224.1839	5.53E-51	3.31	2.97
Aortic atresia ∼	695	10 335 668	115	3 690 429	2.1578	1.7714	2.6284	0.5366	0.4355	0.6195	0.4604	0.3608	0.5444	61.3019	2.45E-15	3.74	2.94
Conjoined twins	190	10 336 173	28	3 967 345	2.6045	1.7516	3.8729	0.6161	0.4291	0.7418	0.5369	0.3456	0.6723	24.1230	4.52E-07	4.65	2.90
Holoprosencephaly ∼	2601	10 333 762	519	3 966 853	1.9236	1.7506	2.1136	0.4801	0.4288	0.5269	0.4003	0.3513	0.4456	191.9022	6.11E-44	3.26	2.90
Respiratory	5185	10 331 178	1028	3 689 517	1.8009	1.6843	1.9255	0.4447	0.4063	0.4806	0.3711	0.3350	0.4053	305.6756	9.56E-69	3.00	2.76
VSD	46 424	10 289 939	10 401	3 956 971	1.7132	1.6772	1.7499	0.4163	0.4038	0.4286	0.3401	0.3285	0.3514	2532.8001	0.00E + 00	2.82	2.74
Neural tube defects	11 338	10 325 024	2487	3 964 885	1.7498	1.6755	1.8274	0.4285	0.4032	0.4528	0.3514	0.3279	0.3741	655.9895	5.57E-145	2.90	2.74
Bilat renal agenesis	1487	10 334 875	306	3 967 066	1.8652	1.6493	2.1094	0.4639	0.3937	0.5259	0.3847	0.3186	0.4444	101.8620	2.98E-24	3.14	2.68
PV stenosis	5118	10 331 245	1128	3 966 244	1.7415	1.6328	1.8575	0.4258	0.3876	0.4616	0.3489	0.3136	0.3824	291.9487	9.35E-66	2.88	2.65
Choanal atresia	1240	10 335 123	256	3 967 116	1.8592	1.6251	2.1269	0.4621	0.3847	0.5298	0.3830	0.3103	0.4481	84.2572	2.17E-20	3.12	2.63
Down syndrome	29 415	10 306 948	6805	3 960 567	1.6591	1.6160	1.7034	0.3973	0.3812	0.4129	0.3226	0.3080	0.3370	1450.7519	9.84E-318	2.70	2.61
Nervous system	36 794	10 299 568	8033	3 682 511	1.6354	1.5964	1.6753	0.3885	0.3736	0.4031	0.3189	0.3053	0.3322	1632.9280	0.00E + 00	2.65	2.57
Double outlet RV	1617	10 334 745	325	3 690 219	1.7764	1.5769	2.0012	0.4371	0.3658	0.5003	0.3639	0.2976	0.4240	91.8471	4.68E-22	2.95	2.53
Encephalocele	1438	10 334 925	310	3 967 062	1.7805	1.5748	2.0129	0.4383	0.3650	0.5032	0.3606	0.2927	0.4220	87.2573	4.76E-21	2.96	2.53
Skeletal dysplasias	2380	10 333 983	531	3 966 841	1.7204	1.5659	1.8900	0.4187	0.3614	0.4709	0.3423	0.2898	0.3910	130.9758	1.25E-30	2.83	2.51
Bile duct A	509	10 335 854	101	3 967 272	1.9343	1.5625	2.3947	0.4830	0.3600	0.5824	0.4030	0.2866	0.5005	38.0366	3.47E-10	3.28	2.50
TV S/A	767	10 335 596	159	3 967 214	1.8515	1.5609	2.1964	0.4599	0.3593	0.5447	0.3809	0.2869	0.4626	51.5808	3.44E-13	3.11	2.50
All anomalies	309 546	10 026 817	75 745	3 891 627	1.5686	1.5563	1.5810	0.3625	0.3574	0.3675	0.2912	0.2867	0.2957	12 889.1510	0.00E + 00	2.51	2.49
Severe CHD	25 055	10 311 308	6065	3 961 307	1.5856	1.5418	1.6307	0.3693	0.3514	0.3868	0.2974	0.2813	0.3130	1058.4314	1.79E-232	2.55	2.46
Anorectal S/A	3430	10 332 933	792	3 966 581	1.6623	1.5387	1.7958	0.3984	0.3501	0.4431	0.3237	0.2799	0.3648	169.8277	4.03E-39	2.71	2.45
Craniosynostosis	4319	10 332 043	1018	3 966 355	1.6284	1.5210	1.7435	0.3859	0.3425	0.4264	0.3123	0.2732	0.3493	199.8699	1.11E-45	2.64	2.41
Cong. cataract	1905	10 334 457	435	3 966 938	1.6809	1.5146	1.8654	0.4051	0.3398	0.4639	0.3298	0.2705	0.3843	97.6924	2.44E-23	2.75	2.40
Eye	5774	10 330 589	1380	3 965 992	1.6060	1.5144	1.7031	0.3773	0.3397	0.4128	0.3045	0.2708	0.3367	254.7824	1.18E-57	2.59	2.40
Vascular disruptions	7593	10 328 770	1732	3 688 812	1.5653	1.4857	1.6491	0.3611	0.3269	0.3936	0.2941	0.2634	0.3234	288.0838	6.50E-65	2.51	2.34
Cong. glaucoma	650	10 335 713	140	3 967 232	1.7821	1.4846	2.1391	0.4388	0.3264	0.5325	0.3611	0.2575	0.4502	39.5357	1.61E-10	2.96	2.33
PV atresia	1435	10 334 928	331	3 967 042	1.6640	1.4766	1.8753	0.3990	0.3228	0.4667	0.3243	0.2553	0.3868	71.2770	1.55E-17	2.72	2.32
Anotia	298	10 336 065	59	3 967 313	1.9387	1.4663	2.5632	0.4842	0.3180	0.6099	0.4042	0.2477	0.5281	22.3830	1.12E-06	3.29	2.29
Hirschsprungs	1562	10 334 800	366	3 967 006	1.6381	1.4619	1.8355	0.3895	0.3159	0.4552	0.3156	0.2495	0.3759	73.7104	4.52E-18	2.66	2.28
Tetralogy of Fallot	3815	10 332 548	943	3 966 430	1.5528	1.4460	1.6675	0.3560	0.3084	0.4003	0.2854	0.2434	0.3251	148.8534	1.54E-34	2.48	2.25
Limb reductions	6606	10 329 757	1663	3 965 710	1.5247	1.4449	1.6089	0.3441	0.3079	0.3785	0.2749	0.2431	0.3054	240.0232	1.94E-54	2.42	2.25
Genital	24 721	10 311 642	6108	3 684 437	1.4451	1.4052	1.4861	0.3080	0.2884	0.3271	0.2470	0.2299	0.2637	672.8740	1.18E-148	2.25	2.16
Hypospadias	20 687	10 315 676	5119	3 685 426	1.4429	1.3995	1.4877	0.3069	0.2854	0.3278	0.2461	0.2274	0.2643	558.8957	7.31E-124	2.24	2.15
Spina bifida	5056	10 331 306	1317	3 966 056	1.4735	1.3868	1.5656	0.3214	0.2789	0.3613	0.2549	0.2182	0.2899	159.0619	9.07E-37	2.31	2.12
Diaphragmatic hernia	3337	10 333 026	866	3 966 507	1.4790	1.3725	1.5938	0.3239	0.2714	0.3726	0.2571	0.2117	0.2999	106.7022	2.59E-25	2.32	2.09
Congenital heart	96 438	10 239 925	24 784	3 665 761	1.3893	1.3701	1.4088	0.2802	0.2701	0.2902	0.2229	0.2143	0.2315	2169.7116	0.00E + 00	2.12	2.08
Annular pancreas	286	10 336 077	63	3 967 309	1.7425	1.3265	2.2889	0.4261	0.2461	0.5631	0.3492	0.1862	0.4795	16.3330	2.66E-05	2.88	1.98
Cleft lip ± palate	7984	10 328 379	2236	3 965 136	1.3705	1.3077	1.4363	0.2703	0.2353	0.3038	0.2112	0.1818	0.2396	175.0977	2.85E-40	2.08	1.94
Transpos grt vess	3798	10 332 564	1042	3 966 330	1.3990	1.3063	1.4983	0.2852	0.2345	0.3326	0.2238	0.1809	0.2644	93.0853	2.50E-22	2.15	1.94
Oesophageal S/A	2927	10 333 436	814	3 966 559	1.3802	1.2771	1.4916	0.2755	0.2169	0.3296	0.2155	0.1664	0.2618	66.7118	1.57E-16	2.10	1.87
Hydrocephalus	6444	10 329 919	1841	3 965 531	1.3435	1.2757	1.4149	0.2557	0.2161	0.2932	0.1989	0.1659	0.2305	125.8285	1.68E-29	2.02	1.87
Orofacial clefts	13 773	10 322 590	3735	3 686 809	1.3166	1.2699	1.3651	0.2405	0.2125	0.2674	0.1892	0.1658	0.2119	223.9970	6.07E-51	1.96	1.86
Gastroschisis	1815	10 334 548	497	3 966 875	1.4017	1.2693	1.5479	0.2866	0.2122	0.3540	0.2250	0.1622	0.2831	44.9227	1.02E-11	2.15	1.85
Arterial truncus	750	10 335 613	195	3 967 177	1.4763	1.2611	1.7282	0.3226	0.2070	0.4213	0.2560	0.1570	0.3435	23.7801	5.40E-07	2.31	1.83
Digestive system	20 789	10 315 573	5754	3 684 791	1.2900	1.2529	1.3282	0.2248	0.2019	0.2471	0.1761	0.1570	0.1947	294.3454	2.81E-66	1.90	1.82
Single ventricle	913	10 335 450	245	3 967 127	1.4303	1.2422	1.6470	0.3009	0.1950	0.3928	0.2372	0.1475	0.3175	25.0121	2.85E-07	2.21	1.79
Syndactyly	4503	10 331 859	1346	3 966 027	1.2841	1.2082	1.3647	0.2212	0.1724	0.2672	0.1703	0.1305	0.2083	65.1528	3.47E-16	1.89	1.71
Cleft palate	5688	10 330 674	1609	3 688 936	1.2622	1.1943	1.3340	0.2077	0.1627	0.2504	0.1619	0.1250	0.1973	68.3469	6.86E-17	1.84	1.68
An/microphthalmos	1347	10 335 016	401	3 966 972	1.2893	1.1533	1.4414	0.2244	0.1329	0.3062	0.1729	0.0987	0.2410	20.0633	3.75E-06	1.90	1.57
Aortic valve S/A	1234	10 335 128	388	3 966 985	1.2207	1.0891	1.3682	0.1808	0.0818	0.2691	0.1376	0.0594	0.2093	11.7826	2.99E-04	1.74	1.40
Mitral valve anomalies	1674	10 334 689	520	3 690 024	1.1494	1.0417	1.2683	0.1300	0.0400	0.2115	0.0992	0.0290	0.1643	7.7067	0.0028	1.56	1.25
PDA	2871	10 333 491	1012	3 966 360	1.0889	1.0136	1.1698	0.0816	0.0134	0.1451	0.0604	0.0092	0.1088	5.4322	0.0099	1.40	1.13
Coarctation aorta	3241	10 333 122	1161	3 966 212	1.0715	1.0020	1.1458	0.0667	0.0020	0.1272	0.0491	0.0010	0.0949	4.0768	0.0217	1.35	1.05
Duodenal S/A	1275	10 335 088	473	3 966 900	1.0346	0.9310	1.1498	0.0335	−0.0741	0.1303	0.0244	−0.0536	0.0967	0.3999	0.2636	1.22	1.00
Klinefelter	798	10 335 564	279	3 967 094	1.0978	0.9579	1.2582	0.0891	−0.0439	0.2052	0.0660	−0.0332	0.1558	1.8022	0.0897	1.43	1.00
Small intestine S/A	1053	10 335 310	394	3 966 978	1.0258	0.9137	1.1517	0.0252	−0.0945	0.1317	0.0183	−0.0680	0.0976	0.1862	0.3330	1.19	1.00
Anophthalmos	191	10 336 172	78	3 967 295	0.9399	0.7223	1.2231	−0.0640	−0.3845	0.1824	−0.0454	−0.2604	0.1329	0.2130	0.3222	1.32	—
ASD	13 356	10 323 007	6183	3 961 190	0.8291	0.8045	0.8545	−0.2061	−0.2430	−0.1703	−0.1409	−0.1646	−0.1176	149.0682	1.39E-34	1.70	—
Ear, face and neck	2475	10 333 888	1232	3 966 140	0.7711	0.7202	0.8256	−0.2969	−0.3886	−0.2112	−0.1982	−0.2541	−0.1448	55.9168	3.78E-14	1.92	—
Indeterminate sex	303	10 336 060	241	3 967 132	0.4826	0.4075	0.5715	−1.0722	−1.4542	−0.7497	−0.5972	−0.7550	−0.4536	74.4764	3.07E-18	3.56	—
Tot anom pul V ret	526	10 335 837	216	3 967 156	0.9347	0.7978	1.0951	−0.0699	−0.2535	0.0868	−0.0495	−0.1742	0.0619	0.6988	0.2016	1.34	—