Table 8:
Multivariate interactive IPW panel regression results by substance at 6 years lag for most significant anomaly term
| Anomaly | Term | Mean Anomaly Rate | ß-Estimate | Standard error | Sigma | T-statistic | Adj. R2 | P-value | E-value estimate | E-value (lower bound) | P-value exponent | Lower E-value exponent | % Increment | P—Bonferroni | P—false discovery rate | P—Holm |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ear, face and neck | lag(LpmResinDailyInt, 6):lag(LpmHerbDailyInt, 6) | 2.4050 | 124.8613 | 31.4481 | 0.7528 | 3.9704 | 0.2145 | 0.0005 | 7.09E + 65 | 3.61E + 33 | 3 | 33 | 198.54 | 0.0139 | 0.0028 | 0.0120 |
| Hip dysplasia | lag(LpmResinDailyInt, 6):lag(LpmHerbDailyInt, 6) | 6.3491 | 107.5064 | 34.7070 | 0.8308 | 3.0975 | −0.3248 | 0.0045 | 2.76E + 51 | 1.40E + 19 | 2 | 19 | 75.21 | 0.1310 | 0.0131 | 0.0908 |
| Hirschsprungs | lag(LpmHerbDailyInt, 6) | 0.9900 | 21.0139 | 4.0517 | 0.2960 | 5.1864 | 0.5242 | 0.0000 | 2.30E + 28 | 6.01E + 17 | 4 | 17 | 457.40 | 0.0005 | 0.0005 | 0.0005 |
| VATER/VACTERL | lag(LpmResinDailyInt, 6):lag(LpmHerbDailyInt, 6) | 0.4798 | 66.1544 | 22.7293 | 0.5441 | 2.9105 | −0.3275 | 0.0071 | 2.25E + 48 | 1.15E + 16 | 2 | 16 | 995.22 | 0.2072 | 0.0139 | 0.1260 |
| PDA | lag(LpmHerbDailyInt, 6) | 2.9086 | 59.4896 | 12.9845 | 0.9484 | 4.5816 | 0.0630 | 0.0001 | 1.23E + 25 | 3.21E + 14 | 4 | 14 | 155.69 | 0.0027 | 0.0009 | 0.0025 |
| Anophthalmos | lag(LpmResinDailyInt, 6):lag(LpmHerbDailyInt, 6) | 0.2059 | 22.2169 | 7.9565 | 0.1905 | 2.7923 | −0.1420 | 0.0095 | 2.52E + 46 | 1.28E + 14 | 2 | 14 | 2319.08 | 0.2754 | 0.0155 | 0.1274 |
| Conjoined twins | lag(LpmResinDailyInt, 6):lag(LpmHerbDailyInt, 6) | 0.1128 | 20.6507 | 7.4064 | 0.1773 | 2.7882 | −0.2137 | 0.0096 | 2.16E + 46 | 1.10E + 14 | 2 | 14 | 4233.14 | 0.2781 | 0.0155 | 0.1274 |
| Congenital heart | lag(Herb, 6) | 82.6649 | 10.2501 | 2.2265 | 0.1814 | 4.6037 | 0.4037 | 0.0001 | 4.35E + 22 | 1.40E + 13 | 4 | 13 | 5.48 | 0.0026 | 0.0009 | 0.0025 |
| Single ventricle | lag(Herb, 6) | 0.7525 | 24.7634 | 5.8151 | 0.4736 | 4.2585 | 0.1922 | 0.0002 | 9.19E + 20 | 2.97E + 11 | 3 | 11 | 601.77 | 0.0065 | 0.0016 | 0.0058 |
| Skeletal dysplasias | lag(LpmHerbDailyInt, 6) | 1.8518 | 30.4938 | 8.0752 | 0.5898 | 3.7762 | −0.0234 | 0.0008 | 5.40E + 20 | 1.41E + 10 | 3 | 10 | 244.54 | 0.0231 | 0.0039 | 0.0191 |
| Syndactyly | lag(LpmResinDailyInt, 6):lag(LpmHerbDailyInt, 6) | 4.2302 | 49.3778 | 19.3916 | 0.4642 | 2.5464 | −0.3173 | 0.0169 | 2.19E + 42 | 1.11E + 10 | 1 | 10 | 112.88 | 0.4902 | 0.0213 | 0.1403 |
| Tot anom pul V ret | lag(Herb, 6) | 0.6242 | 21.1817 | 5.7989 | 0.4723 | 3.6527 | 0.2061 | 0.0011 | 1.06E + 18 | 3.41E + 08 | 2 | 8 | 725.46 | 0.0319 | 0.0046 | 0.0253 |
| Coarctation aorta | lag(Herb, 6) | 3.3779 | 23.2510 | 7.0103 | 0.5710 | 3.3167 | 0.3213 | 0.0026 | 2.48E + 16 | 8.00E + 06 | 2 | 6 | 134.06 | 0.0756 | 0.0095 | 0.0574 |
| Limb | lag(LpmResinDailyInt, 6):lag(LpmHerbDailyInt, 6) | 37.7465 | 42.1716 | 18.0460 | 0.4320 | 2.3369 | −0.3162 | 0.0271 | 7.63E + 38 | 3.88E + 06 | 1 | 6 | 12.65 | 0.7862 | 0.0302 | 0.1403 |
| Anencephalus and ∼ | lag(LpmHerbDailyInt, 6) | 3.5488 | 14.5166 | 4.6598 | 0.3404 | 3.1153 | 0.6029 | 0.0043 | 1.43E + 17 | 3.74E + 06 | 2 | 6 | 127.60 | 0.1254 | 0.0131 | 0.0908 |
| Hydrocephalus | lag(LpmHerbDailyInt, 6) | 5.3737 | 15.9980 | 5.4132 | 0.3954 | 2.9554 | 0.3363 | 0.0064 | 1.95E + 16 | 5.10E + 05 | 2 | 5 | 84.27 | 0.1858 | 0.0139 | 0.1218 |
| Cong. glaucoma | lag(LpmHerbDailyInt, 6) | 0.2853 | 21.4190 | 7.3379 | 0.5360 | 2.9189 | −0.0901 | 0.0070 | 1.24E + 16 | 3.24E + 05 | 2 | 5 | 1587.21 | 0.2031 | 0.0139 | 0.1260 |
| Down syndrome | lag(LpmHerbDailyInt, 6) | 20.7996 | 15.6869 | 5.3918 | 0.3938 | 2.9094 | 0.0850 | 0.0072 | 1.10E + 16 | 2.88E + 05 | 2 | 5 | 21.77 | 0.2078 | 0.0139 | 0.1260 |
| VSD | lag(Herb, 6) | 37.2628 | 8.3593 | 2.8717 | 0.2339 | 2.9109 | 0.2060 | 0.0071 | 2.66E + 14 | 8.60E + 04 | 2 | 4 | 12.15 | 0.2070 | 0.0139 | 0.1260 |
| Edward syndrome | lag(Herb, 6) | 4.9591 | 22.3653 | 7.9587 | 0.6483 | 2.8102 | 0.1626 | 0.0091 | 8.63E + 13 | 2.79E + 04 | 2 | 4 | 91.31 | 0.2639 | 0.0155 | 0.1274 |
| ASD | lag(Herb, 6) | 21.4739 | 20.3234 | 7.4426 | 0.6062 | 2.7307 | −0.1801 | 0.0110 | 3.55E + 13 | 1.15E + 04 | 1 | 4 | 21.09 | 0.3189 | 0.0168 | 0.1274 |
| Patau syndrome | lag(LpmHerbDailyInt, 6) | 1.7507 | 20.3273 | 7.7899 | 0.5690 | 2.6094 | 0.2459 | 0.0146 | 2.63E + 14 | 6.86E + 03 | 1 | 3 | 258.66 | 0.4237 | 0.0202 | 0.1403 |
| Eye | lag(Herb, 6) | 3.6805 | 20.1616 | 7.6754 | 0.6252 | 2.6268 | 0.1091 | 0.0140 | 1.11E + 13 | 3.59E + 03 | 1 | 3 | 123.03 | 0.4069 | 0.0202 | 0.1403 |
| Foetal alcohol | lag(LpmHerbDailyInt, 6) | 0.2577 | 7.1157 | 2.7893 | 0.2037 | 2.5511 | 0.1258 | 0.0167 | 1.27E + 14 | 3.31E + 03 | 1 | 3 | 1757.20 | 0.4849 | 0.0213 | 0.1403 |
| Aortic atresia ∼ | lag(LpmResinDailyInt, 6):lag(LpmHerbDailyInt, 6) | 0.5426 | 32.6821 | 15.3377 | 0.3672 | 2.1308 | −0.1736 | 0.0424 | 3.02E + 35 | 1.54E + 03 | 1 | 3 | 880.06 | 1.0000 | 0.0424 | 0.1403 |
| Respiratory | lag(Herb, 6) | 3.2843 | 18.7230 | 7.6259 | 0.6211 | 2.4552 | 0.4014 | 0.0208 | 1.64E + 12 | 527.8115 | 1 | 2 | 137.88 | 0.6034 | 0.0251 | 0.1403 |
| Digestive system | lag(Herb, 6) | 17.0099 | 6.9501 | 2.9249 | 0.2382 | 2.3762 | 0.2960 | 0.0248 | 6.76E + 11 | 217.9977 | 1 | 2 | 26.62 | 0.7206 | 0.0288 | 0.1403 |
| All anomalies | lag(Herb, 6) | 249.8954 | 4.5283 | 2.0545 | 0.1673 | 2.2041 | 0.5142 | 0.0362 | 9.90E + 10 | 31.4602 | 1 | 1 | 1.81 | 1.0000 | 0.0389 | 0.1403 |
| Choanal atresia | lag(Herb, 6) | 0.9191 | 18.4092 | 8.5330 | 0.6950 | 2.1574 | −0.0434 | 0.0400 | 5.87E + 10 | 18.4553 | 1 | 1 | 492.69 | 1.0000 | 0.0415 | 0.1403 |