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. 2022 Jan 1;6(3):230–242. doi: 10.7150/ntno.61280

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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TSL-Dox release in vivo following intra-tumoural injection. TSL-Dox formulations (LTSL-Dox, TTSL-Dox and NTSL-dox) were injected intratumorally in (A) anaesthetised or (C) euthanized mice. Tumour-bearing legs were immediately immersed in a 43 ºC water bath for 30-60 min, and Dox release was imaged in mice using the IVIS imager. (B and D) are relative Dox fluorescence intensities to zero time point (before HT application) injected in anaesthetised and euthanised mice, respectively. Data are expressed as mean ± S.D (n=3).