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. 2022 Jan 16;6(3):243–255. doi: 10.7150/ntno.65544

Figure 4.

Figure 4

In vivo effects of injected NP based on route of administration. (A) Tumor volumes were measured in mice that received α-PD-L1 NP IP (n=5) versus IV (n=4) until the first mouse reached endpoint as dictated by protocol. Control IgG (n=3) was injected IP as standard practice (200µg/mice, 3 injections over 9 days). (B) Tumor volumes between mice that received control IgG, α-PD-L1 mAb, or α-PD-L1 NP were monitored every 3-4 days post MC38 injection for 3 weeks (n=5 in each group; 200µg/mice, 3 injections over 9 days). (C) Body weight of mice that received control IgG, α-PD-L1 mAb, or α-PD-L1 NP IP were monitored every 3-4 days post MC38 injection for 24-26days (n=5 in each group; left). Spleen weight was measured at the time mice were euthanized (right).