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. 2022 Feb 4;15:761–773. doi: 10.2147/JIR.S350421

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© 2022 Yang et al.

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Summary. Fifty-one women with post-treatment gynecological cancer, including those with unilateral lymphedema (study group, n=25) and those without (control group, n=26). Venous blood samples obtained from the study group before and after LVA and those from the controls were sent for next-generation sequencing, which was validated by real-time PCR. Before LVA, 148 dysregulated genes were identified by NGS. Compared to the controls, 108 and 40 up- and downregulated genes were detected, respectively. After LVA, expression of 78 of the genes was restored to near baseline levels. Of these, 69 had been upregulated (63 protein coding genes, six non-coding genes) and nine had been downregulated.