Fig. 9.
CPC increases zebrafish embryo survival rate following influenza infection. Zebrafish embryos (28 hpf) were injected with 1.0 nL (~ 8.7 × 102 EID50) of APR8 IAV into the duct of Cuvier, for all groups in this figure. Survival curves of IAV-infected zebrafish, ± 0.1 μM CPC treatment for one hour at 6 hpi (A), 24 hpi (B), or 48 hpi (C). Values presented are for a total of ~150 zebrafish, assayed in three independent experiments. Statistically significant differences are represented by ***p < 0.001, ****p < 0.0001, determined by the Mantel-Cox test, the Logrank test, and the Gehan-Breslow-Wilcoxon test of survival curves in GraphPad Prism.