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. 2021 Jun 23;106(12):e5236–e5246. doi: 10.1210/clinem/dgab435

Table 7.

Final surgery decisional rule set (after biopsy)

Rule No. Rule Decision Historical No. of patients that correctly satisfy specific rule Historical No. of patients that correctly satisfy all rules
1 Margin is regular Likely benign–defer surgery 27/27 27/27
Cytology is benign or inadequate (Bethesda 1 or 2)
2 There are no echogenic foci Likely benign-defer surgery 5/5 32/32
Solid component is hypoechoic or markedly hypoechoic
LNs are not visualized or are visualized contralateral to the primary tumor (but not ipsilaterally)
Cytology is benign (Bethesda 2)
3 LNs are not visualized or are visualized contralateral to primary tumor (but not ipsilaterally) Likely benign-defer surgery 4/4 36/36
Cytology is inadequate (Bethesda 1)
4 Solid component is hypoechoic or markedly hypoechoic Likely nonbenign–consider surgery 6/7 42/43
LNs are not visualized or are visualized contralateral to the primary tumor (but not ipsilaterally)
Cytology is indeterminate (Bethesda 3-5)
5 Solid component is isoechoic, hyperechoic or mixed echogenicity Likely nonbenign–consider surgery 3/5 45/48
Hypoechoic halo is absent
Margin is irregular/microlobulated/ spiculated OR indistinct
Cytology is benign or indeterminate (Bethesda 2-5)
6 Otherwise Likely nonbenign–consider surgery 2/5 47/53

Abbreviation: LN, lymph node.