Table 6:
Longitudinal Change in Volume-adjusted Lung Density, Stratified according to Presence or Absence of COPD and according to Parenchymal Emphysema Grades
| Parenchymal Emphysema Grade | COPD (n = 1655) | No COPD (n = 2511) | ||
|---|---|---|---|---|
| Mean Change (g/L) | P Value | Mean Change (g/L) | P Value | |
| Absent | −0.3 (−1.5, 1.0) | .64 | −0.3 (−1.0, 0.4) | .42 |
| Trace | −2.4 (−3.7, −1.1) | <.001 | −1.8 (−2.8, −0.9) | <.001 |
| Mild | −4.6 (−5.7, −3.5) | <.001 | −3.6 (−4.7, −2.6) | <.001 |
| Moderate | −6.7 (−7.7, −5.6) | <.001 | −3.1 (−4.7, −1.5) | <.001 |
| Confluent | −6.4 (−7.6, −5.2) | <.001 | −4.0 (−8.1, 0.2) | .06 |
| ADE | −6.2 (−8.0, −4.5) | <.001 | −17.6 (−35.9, 0.8) | .06 |
Note.—Models are adjusted for age, height, sex, race, and smoking status. Progressions differed by extent of emphysema (P < .001) for each group (COPD or no COPD) and emphysema classification variable. Numbers in parentheses are 95% CIs. ADE = advanced destructive emphysema, COPD = chronic obstructive pulmonary disease.