Table 3.
Univariate and Multivariate Cox regression models for the analysis of factors affecting disease-free survival.
| Univariate Cox | Multivariate Cox | ||||
|---|---|---|---|---|---|
| Regression model | Regression model | ||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Stage | II vs. III | 4.047 | < 0.001 | 3.881 | < 0.001 |
| (2.583-6.342) | (2.109-7.142) | ||||
| Age | < 65 vs. ≥ 65 | 1.572 | 0.024 | 1.489 | 0.054 |
| (1.063-2.324) | (0.994-2.232) | ||||
| Sex | Male vs. Female | 1.163 | 0.460 | ||
| (0.779-1.735) | |||||
| Lymph node | No vs. Yes | 2.410 | 0.003 | 0.864 | 0.716 |
| (1.350-4.305) | (0.393-1.900) | ||||
| Lymphatic invasion | No vs. Yes | 1.932 | 0.004 | 0.666 | 0.408 |
| (1.235-3.024) | (0.254-1.744) | ||||
| Perineural invasion | No vs. Yes | 2.023 | 0.001 | 1.245 | 0.352 |
| (1.327-3.085) | (0.785-1.974) | ||||
| Venous invasion | No vs. Yes | 2.017 | 0.002 | 1.535 | 0.348 |
| (1.304-3.120) | (0.627-3.756) | ||||
| MLH1 | High vs. Low | 0.867 | 0.609 | ||
| (0.501-1.499) | |||||
| MSH2 | High vs. Low | 0.556 (0.176-1.758) |
0.317 | ||
| ARID1A | High vs. Low | 1.059 | 0.805 | ||
| (0.672-1.668) | |||||
| PARP-1 | High vs. Low | 1.443 | 0.058 | 1.547 | 0.026 |
| (0.988-2.109) | (1.054-2.270) | ||||
| BRCA1 | High vs. Low | 1.279 | 0.377 | ||
| (0.741-2.208) | |||||
| ATM | High vs. Low | 1.065 | 0.768 | ||
| (0.768-1.065) | |||||
| Adjuvant | No vs. Yes | 0.452 | 0.001 | 0.596 | 0.032 |
| Chemotherapy | (0.285-0.718) | (0.371-0.957) | |||
ARID1A: AT-rich interaction domain 1; PARP-1: Poly adenosine diphosphate-ribose polymerase 1; BRCA1: Breast cancer susceptibility gene 1; ATM: ataxia-telangiectasia mutated.