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. 2022 Jan 1;13(3):890–905. doi: 10.7150/jca.66903

Figure 8.

Figure 8

Exo-miR-552-5p accelerates tumor growth in vivo. A. Xenograft tumors excised from groups treated with different exosomes and controls. B. Tumor growth curve of xenografts after exosome treatment. C. Tumor weight in each mouse group. D. Immunohistochemical analysis of Ki67 expression in the xenografts (magnification ×200). E. Western blot analysis of PTEN and TOB1 protein expression in the different treatment groups. F. Schematic diagram of how GC cell-derived exosomes containing miR-552-5p may promote tumorigenesis and progression in recipient cells. Exo-miR-552-5p inhibits the PTEN/TOB1 axis to facilitate recipient cell proliferation, migration, metastasis, and EMT, while also inhibiting caspase-3 signaling and apoptosis. *p < 0.05; **p < 0.01; ***p < 0.001.