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. 2021 Sep 9;31(3):440–454. doi: 10.1093/hmg/ddab265

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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FBXO11 variants affect subcellular localization. Schematic drawing of FBXO11 on top left indicates variants with altered subcellular localization in different colors (nuclear exclusion: purple, cytoplasmic aggregates: blue). For immunofluorescence analysis HeLa cells were transiently transfected with 400 ng per 12 well of wildtype or mutant Myc-FBXO11. Cells were fixed 48 h post transfection and stained with an anti-Myc antibody. Images were taken on a Axioimager Z2 with Apotome. Scale bar 20 μM. Arrows point to subcellular aggregates present in several mutants.