Table 2.

Incidence rates for major outcomes in the placebo arm, by ejection fraction

	Left ventricular ejection fraction
	<25% (n = 523)	25–34% (n = 1115)	35–44% (n = 613)	45–54% (n = 1149)	55–64% (n = 1021)	≥65 (n = 437)	P-values for trend
Heart failure hospitalization or cardiovascular death
Patients with events, n (%)	154 (29.4)	255 (22.9)	128 (20.9)	215 (18.7)	161 (15.8)	60 (13.7)
Incidence rate (95% CI)	25.3 (21.5–29.5)	19.1 (16.9–21.5)	12.8 (10.7–15.1)	9.5 (8.3–10.8)	8.0 (6.8–9.2)	7.0 (5.4–8.9)
Hazard ratio (95% CI)	Referent	0.75 (0.61–0.91)	0.54 (0.42–0.68)	0.42 (0.34–0.52)	0.34 (0.27–0.42)	0.29 (0.21–0.39)	<0.001
First heart failure hospitalization
Patients with events, n (%)	113 (21.6)	192 (17.2)	87 (14.2)	139 (12.1)	118 (11.6)	45 (10.3)
Incidence rate (95% CI)	18.6 (15.3–22.2)	14.4 (12.4–16.5)	8.7 (7.0–10.6)	6.1 (5.2–7.2)	5.8 (4.8–6.9)	5.3 (3.9–6.9)
Hazard ratio (95% CI)	Referent	0.77 (0.61–0.97)	0.53 (0.40–0.71)	0.40 (0.31–0.52)	0.36 (0.28–0.47)	0.31 (0.22–0.45)	<0.001
Total (first and recurrent) heart failure hospitalizations
Total hospitalizations, n	179	313	143	218	161	80
Hazard ratio (95% CI)	Referent	0.75 (0.56–1.01)	0.49 (0.35–0.69)	0.36 (0.26–0.49)	0.26 (0.18–0.36)	0.29 (0.19–0.43)	<0.001

CI, confidence interval.