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. 2022 Feb 3;25(2):213–225. doi: 10.1038/s41593-021-00999-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a–c) Differential expression between AD versus control (a), AsymAD versus control (B), and AsymAD versus AD (c). The dashed red line indicates a P value of 0.05, above which proteins are considered significantly differentially expressed. Proteins are colored by the network module in which they reside, according to the module color scheme provided in Fig. 1b. Proteins in the M42 matrisome module are colored lightcyan. One-way ANOVA followed by two-tailed pairwise test was used to calculate P values. Significance was adjusted by the Holm procedure. Fold change and statistics for all proteins are provided in Supplementary Table 2.