Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 3;25(2):213–225. doi: 10.1038/s41593-021-00999-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a, b, Enrichment of AD genetic risk factor proteins as identified by GWAS in TMT AD network modules (a). The dashed red line indicates a Z score of 1.96 (P = 0.05), above which enrichment was considered significant. Enrichment in M42 is driven by ApoE. Modules are ordered by relatedness as illustrated in Fig. 1b. b, Module eigenprotein levels by allele dose (0, 1, 2) for the three SNPs identified as proximal mod-QTLs, separated by case status. M42 rs429358 AsymAD (0, 1) P = 6.9 × 10^–07; M8 rs6940448 AsymAD (0,1) P = 0.003, AsymAD (0, 2) P = 5.5 × 10^–6; M8 rs10458081 AsymAD (0, 1) P = 0.0007, AsymAD (0, 2) P = 6.7 × 10^–5. M42 rs429358 n = 93 control (0), 10 control (1), 138 AsymAD (0), 43 AsymAD (1), 95 AD (0), 51 AD (1), 5 AD (2). M8 rs6940448 n = 52 control (0), 40 control (1), 11 control (2), 80 AsymAD (0), 81 AsymAD (1), 20 AsymAD (2), 60 AD (0), 70 AD (1), 21 AD (2). M8 rs10458081 n = 52 control (0), 40 control (1), 11 control (2), 77 AsymAD (0), 85 AsymAD (1), 19 AsymAD (2), 61 AD (0), 70 AD (1), 20 AD (2). c, M42 matrisome module eigenprotein levels by APOE genotype, separated by case status. AsymAD 2/2 or 2/3 to 3/4 or 4/4 P = 0.0002; AsymAD 3/3 to 3/4 or 4/4 P = 0.005; AD 2/3 to 3/4 or 4/4 P = 0.01. Control n = 20 (2/2 or 2/3), 75 (3/3), 10 (3/4 or 4/4); AsymAD n = 26 (2/2 or 2/3), 122 (3/3), 45 (3/4 or 4/4); AD n = 15 (2/3), 97 (3/3), 66 (3/4 or 4/4). d, ApoE levels by APOE genotype, separated by case status. ApoE is increased in AsymAD and AD, but APOE genotype does not affect ApoE levels. Control n = 20 (2/2 or 2/3), 75 (3/3), 10 (3/4 or 4/4); AsymAD n = 26 (2/2 or 2/3), 122 (3/3), 45 (3/4 or 4/4); AD n = 15 (2/3), 97 (3/3), 66 (3/4 or 4/4). Full statistics are provided in Supplementary Table 26. Differences in eigenprotein levels were assessed by one-way ANOVA with Tukey test. Only significant differences within case status group are shown. *P < 0.05, **P < 0.01 and ***P < 0.001. Box plots represent the median and 25th and 75th percentiles, and box hinges represent the interquartile range of the two middle quartiles within a group. Data points up to 1.5 times the interquartile range from the box hinge define the extent of whiskers (error bars). MHC, major histocompatibility complex.