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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Hum Immunol. 2021 Feb 11;82(5):317–324. doi: 10.1016/j.humimm.2021.01.012

Figure 3. Common features between the autophagy-knockout placenta and human placentas with severe preeclampsia.

Figure 3

Invasion failure and vascular remodeling failure, resulting in small placentas, are common features. Though accumulation of p62 and TFEB downregulation are related to autophagy inhibition, these findings are also observed in both the autophagy-knockout placenta and human preeclampsia placentas. However, fetal size is not decreased in the autophagy-knockout placenta, though the blood pressure is significantly increased in dams.