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Cell survival assays in HT22 cells and HT22 cells transfected with mutant APP cDNA. (A) Cell survival was significantly decreased in mutant APP cells (P = 0.0001) relative to control HT22 cells. However, cell survival was increased in mitophagy enhancers treated mutant APP cells (nicotinamide P = 0.0001 and urolithin A P = 0.0001) relative to mitophagy-enhancer-untreated mutant APP cells.
