Figure S6.

Assessment of intranasal administration of empty vector HuAd:EV and ChAd:EV following SARS-CoV-2 infection, related to Figure 5

(A–C) Representative histopathological images of lungs 14 days post-SARS-CoV-2 MA10 infection in animals intranasally (i.n.) vaccinated with either Tri:HuAd (B) or Tri:ChAd (C), in comparison with unvaccinated controls (A), as per Figure 5A.

(D) Experimental schema.

(E) Changes in body weight over 2 weeks post-SARS-CoV-2 infection.

(F) Viral burden (Log₁₀TCID₅₀) in the lung at 4 days post-SARS-CoV-2 MA10 infection.

Data presented in (E and F) represent mean ± SEM. Statistical analysis for (F) were one-way ANOVA with Tukey’s multiple comparisons test. Data in (E) are representative of 1 independent experiment, n = 5 mice/group. Data in (F) is pooled from 2 independent experiments, n = 10 mice per group. ns, not significant.